| Autor: |
Sarah Crunkhorn, Wagner S. Da Silva, Ryan Faucette, Farrell Dearie, Antonio C. Bianco, Mary-Elizabeth Patti, Daniel Espinoza, Kristen Barry, Christos S. Mantzoros, Hiral Gami |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Journal of Biological Chemistry. 282:15439-15450 |
| ISSN: |
0021-9258 |
| DOI: |
10.1074/jbc.m611214200 |
| Popis: |
Peroxisome proliferator activator receptor-γ coactivator 1 (PGC-1) is a major candidate gene for diabetes-related metabolic phenotypes, contributing to decreased expression of nuclear-encoded mitochondrial genes in muscle and adipose tissue. We have demonstrated that muscle expression of PGC-1α and -β is reduced in both genetic (Lepob/Lepob) and acquired obesity (high fat diet). In C57BL6 mice, muscle PGC-1α expression decreased by 43% (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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