Bicuspid aortic valve is associated with less coronary artery calcium and coronary artery disease burden by computed tomography
| Autor: | Gudrun Feuchtner, Thomas Schachner, Thomas Senoner, Christoph Beyer, Fabian Plank, Nikos Bonaros, Fabian Barbieri, Wolfgang Dichtl, L Stoessl, Sven Bleckwenn, C Gollmann-Tepekoeylue, Johannes Holfeld |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | European Heart Journal. 42 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehab724.0173 |
| Popis: | Background Bicuspid aortic valve (BAV) is associated with genetic defects (NOTCH 1, GATA 5 mutations) and aortopathy. Differences in flow pattern and a genetic predisposition could also affect coronary arteries. Purpose To assess the coronary artery calcium score (CACS) and coronary artery disease (CAD) burden by coronary computed tomography angiography (CTA) in patients with BAV stenosis, as compared to those with tricuspid aortic valve (TAV) stenosis. Methods 47 patients with congenital BAV (68.9 years±12.9, 38.3% females) who underwent cardiovascular CTA for TAVR planning were matched with 47 TAV patients for age, gender, smoking, arterial hypertension, dyslipidemia, diabetes, body-mass-index and chronic kidney disease. The coronary artery calcium score (CACS) (Agatston Units=AU) and coronary stenosis severity by CTA (CADRAD:70/%severe) were quantified. Results The coronary artery calcium score (CACS) was lower in BAV (237.4 vs. 1013.3AU; p More patients with BAV had CACS zero (27.7% vs. 0%, p Obstructive CAD (>50% stenosis) by CTA was more frequently observed in TAV patients (68.1%; p Conclusion Patients with BAV have markedly less coronary artery calcium load and yielded less severe coronary stenosis. CTA succeeds to rule out obstructive CAD in the majority of patients with BAV, with adherent implications for TAVR planning. Funding Acknowledgement Type of funding sources: None. 72 YOM with BAV, zero CACS and no CADCACS was lower in BAV |
| Databáze: | OpenAIRE |
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