Effects of estrogen deficiency on liver function and uterine development: assessments of Medicago sativa's activities as estrogenic, anti-lipidemic, and antioxidant agents using an ovariectomized mouse model
| Autor: | Abdelfattah El Feki, Raed Abdennabi, Fatma Ghorbel Kouba, Hajer Jdidi, Nissaf Aoiadni, Fatma Makni-Ayadi, Mouna Turki |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Antioxidant Physiology medicine.medical_treatment 030209 endocrinology & metabolism Biology medicine.disease_cause Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Internal medicine Hyperlipidemia TBARS medicine Medicago sativa food and beverages General Medicine medicine.disease Endocrinology chemistry 030220 oncology & carcinogenesis Ovariectomized rat Liver function Oxidative stress |
| Zdroj: | Archives of Physiology and Biochemistry. 127:170-181 |
| ISSN: | 1744-4160 1381-3455 |
| Popis: | We investigated the effects of Medicago sativa supplementation on the lipid profiles and antioxidant capacities of ovariectomized mice. The study was performed on white Swiss female mice that were divided into five groups: control, treated with Medicago sativa (0.75 g/kg/day), ovariectomized, ovariectomized treated with β-estradiol (1 μg/day) or with Medicago sativa. The mice were sacrificed after 3 and 8 weeks of treatment. Ovariectomy induced a decrease in overall growth, uterine atrophy, and hyperlipidemia demonstrated by increased cholesterol, triglycerides, and decreased HDL. We have shown the involvement of oxidative stress in this hepatic lesion proven by increased levels of TBARS, GPX, and GSH, and decreased levels of SOD and catalase. Treatment with Medicago sativa restores lipid balance, the activity of antioxidant enzymes and improves lipid peroxidation. This is probably due to the richness of this plant in polyphenols and flavonoids considered as an antioxidant and phytoestrogenic elements. |
| Databáze: | OpenAIRE |
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