Prognostic significance of the degree of lymphatic vessel invasion in locally advanced, surgically resectable pancreatic head cancer
| Autor: | Mio Tamba-Sakaguchi, Masaru Koizumi, Atsushi Miki, Kumiko Mito, Kohei Morita, Toshiro Niki, Toshihide Komatsubara, Yasunaru Sakuma, Makiko Mieno, Noriyoshi Fukushima, Naohiro Sata, Hisashi Oshiro |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment General Medicine Pancreaticoduodenectomy medicine.disease Gastroenterology Metastasis 03 medical and health sciences 0302 clinical medicine Lymphatic system medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine medicine Adjuvant therapy Carcinoma Lymphatic vessel 030211 gastroenterology & hepatology business Lymph node Neoadjuvant therapy |
| Zdroj: | Medicine. 97:e13466 |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000013466 |
| Popis: | Little is known concerning the prognostic significance of the degree of lymphatic vessel invasion in pancreatic head cancer. To address this gap in knowledge, we retrospectively examined 60 patients with locally advanced, surgically resectable pancreatic head cancer who underwent pancreaticoduodenectomy and lymph node (LN) dissection.All cases were histopathologically diagnosed as ductal adenocarcinoma, stage II (25 pT3N0 cases, 35 pT3N1 cases). The following variables were investigated: age; sex; neoadjuvant therapy; adjuvant therapy; tumor size; tumor grade; invasion into the serosa, retropancreatic tissue, duodenum, bile duct, portal venous system and perineural area; cut margins; LN metastasis; and the number of invaded lymphatic vessels (LVI-score).Univariate analysis demonstrated that LN metastasis and an LVI-score ≥5 were significantly associated with poor disease-free survival. Multivariate Cox regression analysis confirmed that LN metastasis and an LVI-score ≥7 were significantly associated with poor disease-free survival. Additionally, LVI-scores ≥9 and ≥10 were comparable to or surpassed the significance of LN metastasis based on the hazard ratio. Univariate analysis demonstrated that tumor size >30 mm, duodenal invasion, LN metastasis and an LVI-score ≥2 were significantly associated with poor overall survival. Multivariate Cox regression analysis confirmed that LN metastasis and LVI-scores ≥9 and ≥10 were significantly associated with poor overall survival, and an LVI-score ≥10 was comparable to or surpassed the significance of LN metastasis based on the hazard ratio.Our study strongly suggests that a high degree of lymphatic vessel invasion is associated with a poor prognosis in patients with locally advanced, surgically resectable pancreatic head cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|