Syntheses of 3H- and 2H-labeled (16S)-15-deoxy-16-hydroxy-16-methyl-5-thiaprostaglandin E1 methyl esters

Autor:	Toshio Tanaka, Seizi Kurozumi, Satoshi Sugiura, Kiyoshi Bannai
Rok vydání:	1991
Předmět:	chemistry.chemical_compound chemistry Hydride Organic Chemistry Drug Discovery Tributyltin Organic chemistry Radiology Nuclear Medicine and imaging Biochemistry Spectroscopy Analytical Chemistry
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 29:1041-1050
ISSN:	0362-4803
Popis:	The syntheses of [7-2H]-, [7-3H]-, and [2,2,3,3,4,4-2H6]-(16S)-15-deoxy-16- hydroxy-16-methyl-5-thiaprostaglandin E1 methyl ester (2, 3, and 4) are described. Both 7-labeled compounds, 2 and 3, were prepared from the Δ7-precursor (11) by treatment with in-situ generated tributyltin deuteride and [3H]hydride, respectively. The hexa-deuterated compound 4 was prepared starting from tetrahydrofuran-d8
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c9818760fba7380dc6e0caa55a04c99b https://doi.org/10.1002/jlcr.2580290909 Zobrazit plný text záznamu Plný text