The activities of basic carboxypeptidases in the nervous system of rats during exercise stress and in response to semax and selank
| Autor: | O. D. Lyubchenko, V. B. Solov’ev, M. T. Gengin, A. A. Stolyarov, M. M. Begutov, O. V. Solov’eva |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty biology Semax Neuropeptide Physical exercise Biological activity Stimulation Biochemistry Carboxypeptidase 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine Endocrinology Carboxypeptidase E Internal medicine medicine biology.protein Selank Psychology Molecular Biology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurochemical Journal. 10:59-63 |
| ISSN: | 1819-7132 1819-7124 |
| Popis: | The effects of exercise stress following single semax and selank administration on the activity of carboxypeptidase E and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase, which are basic carboxypeptidases that are involved in the final stage of processing of biologically active neuropeptide precursors, was studied. The enzyme activity was shown to increase during exercise stress, as well as in response to administration of the peptide agents prior to exercise. The role of basic carboxypeptidases in the mechanisms of semax- and selank-induced stimulation and in the activation of the peptidergic system during physical exercise is discussed. |
| Databáze: | OpenAIRE |
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