Nobiletin, a citrus polymethoxyflavone, enhances the effects of bicalutamide on prostate cancer cellsviadown regulation of NF-κB, STAT3, and ERK activation
| Autor: | Ma Yuran, Nandini Patel, Susan Goodin, Xi Zheng, Xue-Tao Xu, Dongli Li, Kun Zhang, Wenfeng Liu, Xiang Ren, Panpan Wu |
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| Rok vydání: | 2020 |
| Předmět: |
MAPK/ERK pathway
0303 health sciences biology Bicalutamide Chemistry General Chemical Engineering Cancer chemical and pharmacologic phenomena General Chemistry medicine.disease Nobiletin 03 medical and health sciences Prostate cancer chemistry.chemical_compound 0302 clinical medicine Apoptosis 030220 oncology & carcinogenesis Cancer cell medicine biology.protein Cancer research STAT3 030304 developmental biology medicine.drug |
| Zdroj: | RSC Advances. 10:10254-10262 |
| ISSN: | 2046-2069 |
| Popis: | Natural products have shown potential to be combined with current cancer therapies to improve patient outcomes. Nobiletin (NBT) is a citrus polymethoxyflavone and has been shown to exert an anticancer effect in various cancer cells. We investigated the effects and mechanisms of NBT in combination with bicalutamide (BCT), a commonly used anti-androgen drug in prostate cancer therapy, on prostate cancer cells. Our results demonstrate that the combined treatment with NBT and BCT produces an enhanced inhibitory effect on the growth of prostate cancer cells compared to either compound alone. The synergistic action of NBT and BCT was confirmed using isobologram analysis. Moreover, this study has shown that NBT and BCT synergistically inhibited colony formation and migration as well as induced apoptosis. Mechanistic studies demonstrate that NBT and BCT combination reduced key cellular signaling regulators including: p-Erk/Erk, p-STAT3/STAT3 and NF-κB. Overall, these results suggest that NBT combination with BCT may be an effective treatment for prostate cancer. |
| Databáze: | OpenAIRE |
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