High Biocompatible ZIF-8 Coated by ZrO2 for Chemo-microwave Thermal Tumor Synergistic Therapy
| Autor: | Xianwei Meng, Zhongbing Huang, Liuhui Su, Qiang Zhang, Na Xia, Xiaoyan Ma, Qiong Wu, Changhui Fu, Longfei Tan, Xudong Lan, Xiangling Ren, Zengzhen Chen |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Nanocomposite Biocompatibility Nanoparticle Nanotechnology 02 engineering and technology engineering.material 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Coating Drug delivery medicine engineering General Materials Science Doxorubicin Nanocarriers 0210 nano-technology Drug carrier medicine.drug |
| Zdroj: | ACS Applied Materials & Interfaces. 11:10520-10531 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.8b22177 |
| Popis: | The zeolitic imidazolate framework-8 (ZIF-8) is a specifically promising drug carrier due to its excellent intrinsic properties. However, the high toxicity of ZIF-8 nanoparticles severely limits their further research and clinical application. In this work, the biocompatibility of ZIF-8 nanoparticles is greatly improved by coating ZrO2 onto the surface. The survival rate of cells and mice in the ZIF-8@ZrO2 nanocomposite group is significantly increased compared with the undecorated ZIF-8 nanoparticle group. Doxorubicin (DOX) as a chemotherapeutic drug is deposited during the ZIF-8 growth by a facile one-pot method. Ionic liquid (IL) is loaded into the pore of the ZIF-8/DOX@ZrO2 nanocomposites for enhancing microwave thermal therapy. The tumor inhibition rate of ZIF-8/DOX@ZrO2@IL nanocomposites with synergistic microwave thermal therapy and chemotherapy is obviously higher than in other groups. In addition, the ZIF-8/DOX@ZrO2@IL nanocomposites are used for real-time monitoring of the therapeutic outcomes due to the excellent computed tomography contrast agent, ZrO2. Therefore, such a ZrO2 coating strategy shows great promise for overcoming high toxicity of ZIF-8 nanoparticles, which offers a new platform for tumor synergistic microwave thermal therapy and chemotherapy using the ZIF-8/DOX@ZrO2@IL nanocomposite as a theranostic nanocarrier. |
| Databáze: | OpenAIRE |
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