Activity of different subtypes of superoxide dismutase in acute period of ischemic stroke

Autor:	null N. R. Sokhor, null S. I. Shkrobot, null O. Y. Budarna, null A. M. Musiienko
Rok vydání:	2014
Předmět:	General Earth and Planetary Sciences General Environmental Science
Zdroj:	Bukovinian Medical Herald. 18
ISSN:	2413-0737 1684-7903
Popis:	86 patients in the acute period of ischemic stroke (IS) were involved in a study of the activity of general SOD, intracellular (Cu,Zn-SOD), mitochondrial (Mn-SOD2) and numbers of white blood cells with a high content of intracellular reactive oxygen species (ROS+-cells). A reduction of activity of general SOD, Cu,Zn-СОД, Mn-SOD and increase of ROS+-cells number were detected. There was a reliable negative correlation between activity of general SOD, Mn-SOD and the number of ROS+-cells on the 1st day of IS. It was established that the activity of the general SOD, Cu,Zn-СОД, Mn-SOD and number of ROS+-cells depend on the severity of the IS and the infarct size. Credible negative correlations were found at the moderate and severe IS and infarct size 10-100 cm2. A direct reliable correlation between the content of ROS+-cells and degree of the severity and size of the IS were observed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c972fdcab05cdfeb8018d5748827fd81 https://doi.org/10.24061/2413-0737.xviii.4.72.2014.215 Zobrazit plný text záznamu