Hyperglycaemia and insulinopenia in a neonate with cystic fibrosis
| Autor: | Stavros Doudounakis, Dimitris Anagnostakis, Tania Siahanidou, Helen Mandyla |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Pediatrics Glucose tolerance test Pancreatic disease medicine.diagnostic_test business.industry Insulin medicine.medical_treatment Incidence (epidemiology) General Medicine Neonatal age medicine.disease Cystic fibrosis Impaired glucose tolerance Endocrinology Internal medicine Diabetes mellitus Pediatrics Perinatology and Child Health medicine business |
| Zdroj: | Acta Paediatrica. 94:1837-1840 |
| ISSN: | 0803-5253 |
| DOI: | 10.1111/j.1651-2227.2005.tb01864.x |
| Popis: | UNLABELLED Abnormal glucose tolerance is a frequent late complication of cystic fibrosis (CF), but the prevalence of CF-related diabetes mellitus (CFRD) in children less than 10 y old is less than 2%. The youngest child with CFRD reported to date was 6 mo of age. Insulinopenia is the primary cause of abnormal glucose tolerance/CFRD, but it is unknown whether it may begin in the neonatal period. We describe a case of a neonate with CF who presented with hyperglycaemia in the diabetic range and marked insulinopenia. Insulinopenia and impaired glucose tolerance were permanent findings at 6 and 15 mo of age. CONCLUSION This case suggests that abnormal glucose tolerance/diabetes may occur much earlier in the course of CF, even during neonatal age. Careful follow-up and further studies in CF infants could reveal that the real incidence of glucose intolerance and diabetes in this age group has been underestimated. |
| Databáze: | OpenAIRE |
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