Wirksamkeit von Clonidin und Fentanyl als Zusatz bei der postoperativen patientenkontrollierten Epiduralanalgesie mit Bupivacain
| Autor: | S. Tekin, A. Kefi, Nurettin Luleci, T. Erinçler, İsmet Topçu |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Bupivacaine
medicine.medical_specialty Nausea Visual analogue scale business.industry Sedation Analgesic General Medicine Critical Care and Intensive Care Medicine Loading dose Surgery Fentanyl Clonidine Anesthesiology and Pain Medicine Anesthesia Emergency Medicine medicine medicine.symptom business medicine.drug |
| Zdroj: | ains · Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie. 40:521-525 |
| ISSN: | 1439-1074 0939-2661 |
| DOI: | 10.1055/s-2005-870397 |
| Popis: | BACKGROUND AND OBJECTIVES The aim of this prospective randomized double-blinded study was to compare the analgesic and side-effects of bupivacaine in combination with clonidine or fentanyl during patient-controlled-epidural analgesia (PCEA) in the postoperative period after abdominal hysterectomy. METHODS 75 patients from 18 to 65 years of age with ASA status I - II were investigated. After preoperative epidural catheterization, the patients were operated in general anesthesia. After surgery, the patients were randomly allocated to 3 PCEA-groups: Group B 0.125 % bupivacaine, Group F 0.125 % bupivacaine plus 1 microg x ml (-1) fentanyl, Group C 0.125 % bupivacaine plus 0.75 microg x ml (-1) clonidine (10 ml loading dose, 5 ml repetitive bolus dose, 10 min lockout time, 30 ml limit within 4 h). During the following 24 hours, hemodynamic parameters, pain score using visual analog scale (VAS), total analgesic consumption, additional analgesic requirements, sedation, satisfaction, nausea scores and probable side-effects were evaluated. RESULTS Total analgesic consumption was not different between Group F and Group C, but lower than in Group B (p < 0.05). Additional analgesic use was not different between the groups. Group F and Group C had lower VAS-scores in 24 hours than Group B (p < 0.05). Hemodynamic and sedation scores of patients were not different. In Group C, incidence of nausea was lower and satisfaction of patients was higher (p < 0.05). CONCLUSIONS Addition of clonidine or fentanyl to local anesthetics for PCEA can reduce the analgetic demand. Epidural clonidine can reduce postoperative nausea and is connected with higher patients' satisfaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|