HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia

Autor:	James B Robertson, Amy Stieler Stewart, Jennifer Luff, Cecilia Schaaf, Thomas C. Becker, Liara M. Gonzalez, Sara R Tufts, John M. Freund
Rok vydání:	2021
Předmět:	inorganic chemicals Epithelial barrier Hepatology Physiology Intestinal ischemia business.industry Gastroenterology Ischemia medicine.disease digestive system Epithelium medicine.anatomical_structure Physiology (medical) medicine Cancer research Stem cell business
Zdroj:	American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G588-G602
ISSN:	1522-1547 0193-1857
Popis:	This paper supports that rISCs are resistant to ischemic injury and likely an important source of cellular renewal following near-complete epithelial loss. Furthermore, we have evidence that HOPX controls ISC activity state and may be a critical signaling pathway during ISC-mediated repair. Finally, we use multiple novel methods to evaluate ISCs in a translationally relevant large animal model of severe intestinal injury and provide evidence for the potential role of rISCs as therapeutic targets.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c972715325df30e5198a5f4d786f4dcd https://doi.org/10.1152/ajpgi.00165.2021 Zobrazit plný text záznamu