Contrast-enhancing tumor growth dynamics of preoperative, treatment-naive human glioblastoma
| Autor: | Benjamin M. Ellingson, Okkar Zaw, Timothy F. Cloughesy, Whitney B. Pope, Linda M. Liau, Phioanh L. Nghiemphu, Albert Lai, William H. Yong, Huytram N. Nguyen, Ruben Nechifor |
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| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
medicine.diagnostic_test business.industry Radiography media_common.quotation_subject Cancer Magnetic resonance imaging medicine.disease 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Cohort medicine Contrast (vision) Doubling time business Nuclear medicine 030217 neurology & neurosurgery Progressive disease Glioblastoma media_common |
| Zdroj: | Cancer. 122:1718-1727 |
| ISSN: | 0008-543X |
| DOI: | 10.1002/cncr.29957 |
| Popis: | Author(s): Ellingson, Benjamin M; Nguyen, Huytram N; Lai, Albert; Nechifor, Ruben E; Zaw, Okkar; Pope, Whitney B; Yong, William H; Nghiemphu, Phioanh L; Liau, Linda M; Cloughesy, Timothy F | Abstract: BackgroundLittle is known about the natural growth characteristics of untreated glioblastoma before surgical or therapeutic intervention, because patients are rapidly treated after preliminary radiographic diagnosis. Understanding the growth characteristics of uninhibited human glioblastoma may be useful for characterizing changes in response to therapy. Thus, the objective of the current study was to explore tumor growth dynamics in a cohort of patients with untreated glioblastoma before surgical or therapeutic intervention.MethodsNinety-five patients with glioblastoma who had measurable enhancing disease on g2 magnetic resonance imaging scans before surgery were identified. Tumor growth rates were quantified in 4 different ways (the percentage change per day, the absolute rate of change per day, the estimated volumetric doubling time, and the radial expansion rate) using 3 different approaches (bidirectional product, enhancing disease, and total lesion volume).ResultsThe median volumetric doubling time was 21.1 days, the percentage change in tumor volume was 2.1% per day, and the rate of change in total lesion volume was 0.18 cc per day. The length of follow-up between magnetic resonance imaging examinations should be g28 days to detect progressive disease with high specificity. Small initial tumor sizes (l3 cm in greatest dimension) are biased toward a large percentage change at follow-up.ConclusionsPresurgical, treatment-naive glioblastoma growth dynamics can be estimated in a variety of ways with similar results. The percentage changes in tumor size and volume depend on baseline tumor size and the time interval between scans. Cancer 2016;122:1718-27. © 2016 American Cancer Society. |
| Databáze: | OpenAIRE |
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