| Autor: |
Natale Vazzana, Francesca Santilli, Giovanni Davì |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Antiplatelet Agents ISBN: 9783642294228 |
| Popis: |
Atherothrombosis is the major cause of mortality and morbidity in Western countries. Several clinical conditions are characterized by increased incidence of cardiovascular events and enhanced thromboxane (TX)-dependent platelet activation. Enhanced TX generation may be explained by mechanisms relatively insensitive to aspirin. More potent drugs possibly overcoming aspirin efficacy may be desirable. Thromboxane synthase inhibitors (TXSI) and thromboxane receptor antagonists (TXRA) have the potential to prove more effective than aspirin due to their different mechanism of action along the pathway of TXA2. TXSI prevent the conversion of PGH2 to TXA2, reducing TXA2 synthesis mainly in platelets, whereas TXRA block the downstream consequences of TXA2 receptors (TP) activation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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