Pharmacokinetics of Calcium Absorption from Two Commercial Calcium Supplements

Autor:	Alan Stewart, Howard J. Heller, Charles Y.C. Pak, Sharon Haynes
Rok vydání:	1999
Předmět:	Pharmacology Calcium metabolism medicine.medical_specialty Meal business.industry Area under the curve chemistry.chemical_element Calcium Placebo Preload Endocrinology Pharmacokinetics chemistry Oral administration Internal medicine Medicine Pharmacology (medical) business
Zdroj:	The Journal of Clinical Pharmacology. 39:1151-1154
ISSN:	1552-4604 0091-2700
DOI:	10.1177/009127009903901106
Popis:	This study was conducted to compare pharmacokinetic indices of calcium absorption after a single oral (500 mg calcium) load of Citracal (calcium citrate) and Os-Cal (calcium carbonate). In 18 postmenopausal normal women, venous blood samples were obtained for the measurement of calcium before and hourly for 6 hours after an oral ingestion of Citracal, Os-Cal, or placebo with a breakfast meal. The change in area under the curve (ΔAUC) in serum calcium from preload was 2.5-fold greater for Citracal than Os-Cal, and the peak-basal variation in serum calcium was 76% higher for Citracal than Os-Cal. The increment in serum calcium from preload after Citracal administration was significantly higher than that obtained after placebo load during most time periods and significantly higher than that of Os-Cal at 1, 4, and 5 hours after load. In contrast, ΔAUC and peak basal variation of Os-Cal did not differ significantly from placebo, and increment in serum calcium was significantly increased from placebo only at 6 hours. In conclusion, Citracal is much more bioavailable than Os-Cal.
Databáze:	OpenAIRE
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