Increased serum concentrations of Nɛ-carboxymethyllysine are related to the presence and the severity of rheumatoid arthritis
| Autor: | Mohamed Hammami, Ines Knani, Naceur Bergaoui, Hassan Bouzidi, Mohsen Kerkeni, Saoussen Zrour |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Cross-sectional study business.industry Clinical Biochemistry Case-control study General Medicine 030204 cardiovascular system & hematology Serum concentration medicine.disease Control subjects Gastroenterology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Glycation Rheumatoid arthritis Internal medicine Severity of illness medicine Pentosidine business |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 55:430-436 |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1177/0004563217733500 |
| Popis: | BackgroundThere are limited data regarding the contribution of advanced glycation end products in the presence of rheumatoid arthritis. We investigated whether serum Nɛ-carboxymethyllysine and pentosidine were related to the presence and the severity of rheumatoid arthritis.MethodsEighty patients with rheumatoid arthritis and 30 control subjects were included in a cross-sectional study. The severity of rheumatoid arthritis was assessed using the disease activity score for 28 joints. Serum Nɛ-carboxymethyllysine and pentosidine were measured by enzyme-linked immunosorbent assay.ResultsSerum Nɛ-carboxymethyllysine and pentosidine concentrations were significantly higher in patients with rheumatoid arthritis vs. control subjects ( P ɛ-carboxymethyllysine and pentosidine concentrations were significantly higher in rheumatoid arthritis patients with high disease activity vs. rheumatoid arthritis patients with moderate disease activity ( P ɛ-carboxymethyllysine was independently associated with the presence of rheumatoid arthritis (OR = 1.21, 95% CI: 1.05–1.39, P = 0.006). Furthermore, in a multivariate stepwise regression analysis, Nɛ-carboxymethyllysine was independently correlated with disease activity score for 28 joints (standardized β = 0.43, P = 0.001).ConclusionSerum Nɛ-carboxymethyllysine and pentosidine were increased during rheumatoid arthritis, and Nɛ-carboxymethyllysine was independently associated with the presence and the severity of rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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