HHV8 and female Kaposi's sarcoma

Autor: James O'd. McGee, M M Kennedy, Angela Bardon, Steve J. Picton, Iain L. Comley, D D Howells, John J. O'Leary, Robin Russell-Jones, Sebastian Lucas
Rok vydání: 1997
Předmět:
Zdroj: The Journal of Pathology. 183:447-452
ISSN: 1096-9896
0022-3417
DOI: 10.1002/(sici)1096-9896(199712)183:4<447::aid-path954>3.0.co;2-q
Popis: Kaposi's sarcoma (KS) is an enigmatic tumour of uncertain histogenesis. Epidemiological data have long suggested that KS may be caused by an infectious agent, possibly sexually transmitted. Following the documentation of human herpesvirus 8 (HHV8) and its strong association with all forms of KS, it now appears that the putative agent has at last been identified. As KS is rare in females, a unique group was screened for the presence of HHV8 using both conventional solution-phase polymerase chain reaction (PCR) and the newly described technique of TaqMan PCR. The presence of HHV8 was demonstrated in 10/12 of these female patients. This further supports the direct role of HHV8, in conjunction with cytokines and other factors, in the pathogenesis of KS.
Databáze: OpenAIRE
Externí odkaz: