Pancitopenia inducida por azatioprina. Casos clínicos
| Autor: | López Campos M, Martínez Faci C, Martínez de Zabarte Fernández Jm, Rodríguez-Vigil Iturrate C, Sorribes Estorch J, Ros Arnal I |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Leukopenia Thiopurine methyltransferase biology business.industry medicine.drug_class medicine.medical_treatment Metabolite Antibiotics Azathioprine medicine.disease Pancytopenia Gastroenterology Inflammatory bowel disease chemistry.chemical_compound Immunosuppressive drug chemistry Internal medicine Pediatrics Perinatology and Child Health medicine biology.protein medicine.symptom business medicine.drug |
| Zdroj: | archivos Argentinos de Pediatria. 114 |
| ISSN: | 0325-0075 |
| DOI: | 10.5546/aap.2016.e252 |
| Popis: | Azathioprine is an immunosuppressive drug that has shown effectiveness in inflammatory bowel disease treatment. Its metabolite, 6-mercaptopurine, is metabolized through thiopurine methyltransferase. Patients with low enzyme activity may have more frequent and severe side effects. The most common is leukopenia, and rarely pancytopenia. The thiopurine methyltransferase activity monitoring shows an individualized profile of enzymatic activity but it should not replace monitoring by performing serial blood counts. In patients with fever and severe neutropenia, early empirical antibiotic treatment should be initiated to prevent severe and disseminated infection. Two patients with this condition are reported. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|