Where and when natriuretic peptides are secreted in the heart

Autor: V. F. Maksimov, I. M. Korostyshevskaya
Rok vydání: 2012
Předmět:
Zdroj: Russian Journal of Developmental Biology. 43:185-195
ISSN: 1608-3326
1062-3604
DOI: 10.1134/s1062360412030046
Popis: This review presents recent data on the structure, synthesis, and secretion of cardiac natriuretic peptides. It is known that these hormones have a broad spectrum of activity, but they remain the least studied and poorly understood link in the regulation of the water-salt homeostasis. Emphasis is placed on the problem of ontogenetic formation of the heart secretory activity during embryogenesis. We discuss the available scarce and scattered information on the paracrine and autocrine effects of the peptides on intercellular interactions, and on the division, growth and differentiation of the heart cells. These issues are hardly addressed in Russian literature.
Databáze: OpenAIRE