Plasma copeptin and metabolic dysfunction in individuals with bipolar disorder
| Autor: | Mariana Pedrini, Rodrigo B. Mansur, Graccielle R. Cunha, Quirino Cordeiro, Elisa Brietzke, Mariane N. Noto, Elson Asevedo, Camila M. Santos, Lucas B. Rizzo, Maiara Zeni-Graiff, Roger S. McIntyre |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Population 03 medical and health sciences 0302 clinical medicine Insulin resistance Copeptin Internal medicine medicine Bipolar disorder education education.field_of_study Adiponectin business.industry General Neuroscience Leptin Type 2 Diabetes Mellitus General Medicine medicine.disease 030227 psychiatry Psychiatry and Mental health Endocrinology Neurology Neurology (clinical) business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry and Clinical Neurosciences. 71:624-636 |
| ISSN: | 1323-1316 |
| DOI: | 10.1111/pcn.12535 |
| Popis: | AIM This study aimed to compare plasma copeptin levels, the c-terminal of provasopressin, between individuals with bipolar disorder (BD) and healthy controls and to assess the relation between copeptin and metabolic parameters. METHODS We measured plasma levels of copeptin in individuals with BD (n = 55) and healthy controls (n = 21). Information related to psychiatric/medical history, as well as to metabolic comorbidities and laboratorial parameters was also captured. Insulin resistance and β-cell function in basal state were calculated from fasting plasma glucose and C-peptide using the HOMA2 calculator. Impaired glucose metabolism was defined as pre-diabetes or type 2 diabetes mellitus. Copeptin, adiponectin, and leptin plasma levels were determined by enzyme-linked immunosorbent assay. RESULTS Plasma copeptin levels were lower in individuals with BD, relative to healthy controls (P |
| Databáze: | OpenAIRE |
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