| Autor: |
John L. Ziegler |
| Rok vydání: |
2015 |
| Předmět: |
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| Popis: |
This paper reviews current theories on the etiology of acquired immunodeficiency syndrome (AIDS) recent advances in the mechanisms of oncogenesis and the relationship of immunodeficiency to the development of cancer. It then attempts to synthesize these concepts into a hypothesis to explain the AIDS-cancer connection. 2 major theories have been advanced to explain the etiology of AIDS. The 1st postulates a viral infection of T helper lymphocytes leading to cell destruction and secondary immunodysregulation while the 2nd postulates that AIDS is mainly a B cell disease with T cell destruction as a secondary consequence. In either case progressive irreversible immunodeficiency results in greatly increased susceptibility to lymphoreticular neoplasia and severe opportunistic infections. Of considerable relevance to the AIDS epidemic is an association between cytomegalovirus and Kaposis sarcoma. DNA virus infection is probably 1 of many possible cellular insults that perturb the resting state induce proliferation and increase the chance of genetic accidents that lead to cancer. Available knowledge suggests the outlines of possible mechanisms for the development of Kaposis sarcoma and non-Hodgkins lymphoma in AIDS patients. An obvious susceptibility factor appears to be the high prevalence of virus infections in the AIDS risk groups and virtually all of these viruses are associated with human cancer. Thus activation of these endogenous viruses by an immunodysregulated state could lead to perturbation of the resting state of the host cells. A central question is why Kaposis sarcoma and non-Hodgkins lymphoma shadow homosexual AIDS patients. It is suggested that AIDS should be viewed as a primary lymphoproliferative disorder. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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