The Tumor Biology Of Gastrin And Cholecystokinin
| Autor: | Rehfeld Jf, van Solinge Ww |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Clinical Oncology
medicine.medical_specialty Tumor biology digestive oral and skin physiology Cancer Peptide hormone Biology medicine.disease digestive system Endocrinology Gastrointestinal hormone Internal medicine Gene expression medicine hormones hormone substitutes and hormone antagonists Cholecystokinin Gastrin |
| Popis: | Publisher Summary This chapter discusses the tumor biology of gastrin and cholecystokinin (CCK) by giving a description of the normal biology of the gastrin and CCK systems followed by a discussion of the expression and growth stimulation of gastrin and CCK peptides in carcinomas, sarcomas, and benign tumors. The novel methods for the measurement of gastrin and CCK expression in experimental and clinical oncology have been mentioned. The single most important aspect in gastrin and CCK tumor biology is the possible involvement of gastrin in the development of several common carcinomas. Expression of the gastrin gene has been found not only in colorectal carcinomas, but also in bronchial, ovarian, pancreatic, and apparently some gastric carcinomas. Specific aspects of the association between gastrin or CCK, and cancer have been reviewed. However, because the emphasis has been on clinical correlations, a more comprehensive review including the basic aspects is needed. |
| Databáze: | OpenAIRE |
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