A comparative examination of odontogenic markers in both toothed and toothless amniotes (344.3)
| Autor: | Kathleen K. Smith, Ralph S. Marcucio, Keijo Hämäläinen, Diane Hu, Leslea J. Hlusko, Aki Kallonen, Alexis Lainoff, Jacqueline Moustakas |
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| Rok vydání: | 2014 |
| Předmět: |
animal structures
Alligator Biochemistry 03 medical and health sciences 0302 clinical medicine FGF8 stomatognathic system biology.animal Genetics Tooth loss medicine American alligator Molecular Biology 030304 developmental biology 0303 health sciences biology Dentition biology.organism_classification Phenotype Odontogenic stomatognathic diseases Evolutionary biology embryonic structures Mammal medicine.symptom 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | The FASEB Journal. 28 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fasebj.28.1_supplement.344.3 |
| Popis: | It is a well-known tenet of murine tooth development that BMP4 and FGF8 antagonistically initiate odontogenesis, but it is largely unexplored whether this tenet is conserved across amniotes. Additionally, changes in BMP4-signaling have previously been implicated in evolutionary tooth loss in Aves. Here we demonstrate that Bmp4, Msx1, and Msx2 expression is limited proximally in the red-eared slider turtle (Trachemys scripta) mandible, at stages equivalent to those at which tooth development is initiated in mice, similar to previously reported results in chicks. To address the question of whether the limited domains shared between the turtle and the chicken are indicative of an evolutionary molecular parallelism that resulted in the loss of the dentition, or whether the domains simply constitute an ancestral phenotype, we assessed expression of Bmp4, Msx1, Msx2, and Fgf8 expression in a toothed reptile (the American alligator, Alligator mississippiensis) and a toothed non-placental mammal (the Gray short-t... |
| Databáze: | OpenAIRE |
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