A STUDY ON PREDICTING FACTORS OF THE EFFECT OF INTRA-ARTERIAL INFUSION CHEMOTHERAPY IN PATIENTS WITH BLADDER CANCERS

Autor: Shin-ichiro Yamada, Yoshinori Fujimoto, Kazutoshi Isogai, Takashi Deguchi, Shinichi Nezasa, Shogo Kawamoto, Yasuyuki Nishida, Masayoshi Tamaki, Hidetoshi Ehara, Yoshito Takahashi, Manabu Okano, Toshimi Takeuchi, Yukimichi Kawada, Takuji Tanaka
Rok vydání: 1994
Předmět:
Zdroj: The Japanese Journal of Urology. 85:1528-1533
ISSN: 1884-7110
0021-5287
Popis: We studied a relationship between in vitro sensitivity of the tumors to anti-cancerous drugs and histopathological effectiveness of an intra-arterial infusion chemotherapy in 15 patients with bladder cancers. The in vitro sensitivity test was performed by measuring intra-cellular ATP contents (ATP assay). The intra-arterial chemotherapy were performed by injecting methotrexate (MTX), adriamycin (ADM) and eisplatin (CDDP) from the internal iliac artery. When the intra-cellular ATP contents of the tumor cells treated with an anti-cancerous drug decreased to less than 50% of the untreated tumor cells, the tumor was evaluated as sensitive to the drug. The effectiveness of the chemotherapy were histopathologically evaluated by a pathologist according to the response criteria for bladder cancer treatment. When the histopathological responses of higher than grade 2 were observed in the tumor, the chemotherapy was evaluated as effective. In 8 of 9 tumors sensitive to ADM, chemotherapy were effective histopathologically and in all 6 tumors resistant to ADM, histopathological response of the chemotherapies were poor. The overall coincidence ratio between sensitivity to ADM and the histopathological effectiveness of the chemotherapy was 93%, showing statistically significant correlation. In 7 of 12 tumors sensitive to CDDP, the chemotherapies were effective and in 2 of 3 tumors resistant to CDDP, the chemotherapies were ineffective. Although the overall coincidence ratio between the sensitivities to CDDP and chemotherapeutic effectiveness was 60%, there was no significant correlation between them. In 7 of 8 tumors sensitive to both of ADM and CDDP, the chemotherapies were effective and in 6 of 7 tumors resistant to at least one of them, the chemotherapies were ineffective. (ABSTRACT TRUNCATED AT 250 WORDS)
Databáze: OpenAIRE
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