Vitamina B12 en pacientes diabéticos tipo 2 en tratamiento con metformina
| Autor: | José María Calvo Romero, José Manuel Ramiro Lozano |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Vitamin b
Drug medicine.medical_specialty endocrine system diseases Cross-sectional study business.industry Endocrinology Diabetes and Metabolism media_common.quotation_subject nutritional and metabolic diseases medicine.disease Gastroenterology Cobalamin Metformin chemistry.chemical_compound Endocrinology chemistry Internal medicine Diabetes mellitus medicine Outpatient clinic Vitamin B12 business medicine.drug media_common |
| Zdroj: | Endocrinología y Nutrición. 59:487-490 |
| ISSN: | 1575-0922 |
| DOI: | 10.1016/j.endonu.2012.06.005 |
| Popis: | Objective To test vitamin B12 plasma levels in type 2 diabetic patients treated with metformin in our area. Methods A cross-sectional, observational study of consecutive type 2 diabetic patients on drug treatment attending an internal medicine outpatient clinic. Results One hundred and nine patients (81 treated with metformin) were enrolled into the study. Mean time on metformin treatment was 43.5 months and mean drug dose was 1,779 mg/day. Patients treated with metformin had significantly lower vitamin B(12) plasma levels (393.5 vs. 509 pg/mL, P = .0008). Seven (8.6%) of 81 patients treated with metformin and none of the 28 patients not treated with the drug had vitamin B(12) plasma levels lower than 197 pg/mL. No correlation was found between vitamin B12 plasma levles and metformin treatment time or dosage. Conclusions In type 2 diabetic patients, treatment with metformin is associated to lower vitamin B12 plasma levels. Vitamin B12 deficiency associated with metformin is relatively common in our area. |
| Databáze: | OpenAIRE |
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