ChemInform Abstract: Caeruleanone A, a Rotenoid with a New Arrangement of the D-Ring from the Fruits of Millettia caerulea

Autor:	A. Douglas Kinghorn, Hee Byung Chai, Lynette Bueno Pérez, Li Pan, Esperanza J. Carcache de Blanco, Djaja Djendoel Soejarto, Ulyana Muñoz Acuña, Judith C. Gallucci, Tran Ngoc Ninh, Jie Li
Rok vydání:	2014
Předmět:	chemistry.chemical_compound biology Chemistry Stereochemistry General Medicine Reductase biology.organism_classification Caerulea Rotenoid Quinone Millettia
Zdroj:	ChemInform. 45
ISSN:	0931-7597
DOI:	10.1002/chin.201434214
Popis:	Caeruleanone A (1), a novel rotenoid with an unprecedented arrangement of the D-ring, was isolated with another two new analogues, caeruleanones B (2) and C (3), together with 11 known rotenoids from the fruits of Millettia caerulea. The structures of the new compounds were determined by spectroscopic data analysis, with that of 1 being confirmed by single-crystal X-ray diffraction. Compounds 2 and 3 displayed potent mitochondrial transmembrane potential inhibitory and quinone reductase induction activities.
Databáze:	OpenAIRE
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