Solvent Based 3D Printing of Biopolymer/Bioactive Glass Composite and Hydrogel for Tissue Engineering Applications
| Autor: | Krishna C. R. Kolan, Julie A. Semon, Ming-Chuan Leu, Caroline Murphy, Yong Liu, Jakeb Baldridge, Delbert E. Day |
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| Rok vydání: | 2017 |
| Předmět: |
3D bioprinting
Scaffold Materials science Composite number technology industry and agriculture Borate glass macromolecular substances 02 engineering and technology engineering.material 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences law.invention Tissue engineering law Bioactive glass Self-healing hydrogels engineering General Earth and Planetary Sciences Biopolymer Composite material 0210 nano-technology General Environmental Science |
| Zdroj: | Procedia CIRP. 65:38-43 |
| ISSN: | 2212-8271 |
| DOI: | 10.1016/j.procir.2017.04.022 |
| Popis: | Three-dimensional (3D) bioprinting is an emerging technology in which scaffolding materials and cell-laden hydrogels may be deposited in a pre-determined fashion to create 3D porous constructs. A major challenge in 3D bioprinting is the slow degradation of melt deposited biopolymer. In this paper, we describe a new method for printing poly-caprolactone (PCL)/bioactive borate glass composite as a scaffolding material and Pluronic F127 hydrogel as a cell suspension medium. Bioactive borate glass was added to a mixture of PCL and organic solvent to make an extrudable paste using one syringe while hydrogel was extruded and deposited in between the PCL/borate glass filaments using a second syringe. The degradation of the PCL/borate glass composite scaffold with and without the presence of hydrogel was investigated by soaking the scaffold in minimum essential medium. The weight loss of the scaffold together with formation of a hydroxyapatite-like layer on the surface shows the excellent bioactivity of the scaffold. |
| Databáze: | OpenAIRE |
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