NH4I-catalyzed chalcogen(S/Se)-functionalization of 5-membered N-heteroaryls under metal-free conditions

Autor:	Marcelo S. Franco, Luana Bettanin, Jamal Rafique, Marcelo Godoi, Sumbal Saba, Carlos V. Doerner, Antonio L. Braga
Rok vydání:	2018
Předmět:	Indole test Indazole C h bond 010405 organic chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Chalcogen Acetic acid chemistry Metal free Drug Discovery Surface modification
Zdroj:	Tetrahedron. 74:3971-3980
ISSN:	0040-4020
DOI:	10.1016/j.tet.2018.05.084
Popis:	Herein, we described the NH4I-catalyzed C H bond chalcogenation of N-heteroaryls in the presence of a minimum amount of DMSO/H2O/acetic acid as additives (2.5/2.5/1 M equiv., respectively), under metal-free conditions. Under optimized conditions, a wide variety of sulfenyl/selenyl imidazo[1,2-α]pyridines were prepared in very good yields. Moreover, the present approach was also highly efficient for the chalcogenation of different 5-membered N-heteroaryls, e.g., indole, imidazothiazole, indazole and imidazopyrimidine derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c91eaedfd3b7b7550445d8f65e62b734 https://doi.org/10.1016/j.tet.2018.05.084 Zobrazit plný text záznamu Full Text from ScienceDirect