Thermodynamic and kinetic mechanism of phase transformation of levofloxacin hydrochloride
| Autor: | Han Liu, Shanshan Yu, Xiunan Zhang, Yuyuan Dong, Na Wang, Hongxun Hao, Xin Huang, Ting Wang, Kui Chen |
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| Rok vydání: | 2022 |
| Předmět: |
Work (thermodynamics)
Materials science Hydrochloride General Chemical Engineering Thermodynamics Atmospheric temperature range chemistry.chemical_compound symbols.namesake chemistry Transition point Phase (matter) symbols General Materials Science Thermal stability Dynamic vapor sorption Raman spectroscopy |
| Zdroj: | Particuology. 66:59-70 |
| ISSN: | 1674-2001 |
| Popis: | In this work, thermodynamic and kinetic factors that affect formation and phase transformation process of different solid forms of levofloxacin hydrochloride were investigated in detail. Dynamic vapor sorption experiments (DVS) and varying temperature-powder X-ray diffraction (VT-PXRD) experiments were carried out to study moisture-dependent stability, thermal stability as well as the transformation process between Form I and Form II. Critical water activities of levofloxacin hydrochloride were determined in temperature range of 5.0–45.0 °C. Raman spectroscopy was applied to in situ monitor the temperature-induced phase transformation and the hydration process of levofloxacin hydrochloride, and one possible mechanism consisting of multiple chemical equilibria was proposed to analyze the effect of thermodynamic and kinetic factors on the formation and transformation of different solid forms. Results show that the anhydrate, Form II would transform to the monohydrate, Form I more easily with the increasing water content. And the transition point moves toward higher water contents as the temperature increases. The results suggested that, except for thermodynamic factors, kinetic factors also play an essential role in controlling the solid forms of polymorphic compounds. |
| Databáze: | OpenAIRE |
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