Bioactive carbazole alkaloids from Alysicarpus ovalifolius (Schumach)

Autor:	Pauline N. M. Mwinzi, Sylvia A. Opiyo, Lawrence A.O. Manguro, Angeline Atieno Ochung, Hosea Akala, Isaac O. Jondiko, Regina Nyunja, Phillip Okinda Owuor
Rok vydání:	2015
Předmět:	Orientin Stigmasterol Stereochemistry Organic Chemistry Plumbagin Biology Antimicrobial General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound chemistry Phytochemical Apigenin Kaempferol Quercetin
Zdroj:	Journal of the Korean Society for Applied Biological Chemistry. 58:839-846
ISSN:	2234-344X 1738-2203
Popis:	Phytochemical and biological evaluation of the stem bark of Alysicarpus ovalifolius led to the isolation of three carbazole alkaloids identified as mohanimbine (1), koenimbine (2) and koenidine (3) along with quercetin 3-O-glucoside (4), kaempferol 7-O-glucoside (5), orientin (6), apigenin (7), quercetin (8), plumbagin (9) and stigmasterol (10). The structures of these compounds were elucidated using physical and spectroscopic methods as well as comparison with the literature data. Compound 3 showed strong activity against chloroquine-sensitive strain I (D6) and the multi-drug resistant Indochicha I (W2) of Plasmodium falciparum with IC50 values of 63.07 ± 0.01 and 54.19 ± 0.04 ng/mL, respectively. Compound 1 on the other hand exhibited moderate larvicidal against Anopheles gambiae larvae as well as antimicrobial activities against Candida albicans and gram-positive Staphylococcus aureus, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c91a53e2f9bfa91fc1f72109e385783c https://doi.org/10.1007/s13765-015-0100-4 Zobrazit plný text záznamu