Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure1
| Autor: | Yong-Xiao Cao, Hong-yan Tian, Zhi Hu, Jian-Hua Huo, Aiqun Ma, Li-Hong Fan |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pharmacology
medicine.medical_specialty Aorta ATP-sensitive potassium channel business.industry General Medicine Potassium channel Laboratory rat Electrophysiology Endocrinology medicine.anatomical_structure Blood pressure Internal medicine medicine.artery Gene expression medicine Pharmacology (medical) business Mesenteric arteries |
| Zdroj: | Acta Pharmacologica Sinica. 29:1167-1174 |
| ISSN: | 1745-7254 1671-4083 |
| DOI: | 10.1111/j.1745-7254.2008.00810.x |
| Popis: | Aim: To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure. Methods: Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, K ATP channel-mediated relaxation responses in the aortas and mesenteric arteries, K ATP channel current, and gene expression were examined, respectively. Results: Blood pressure and body weight were increased in rats fed with high-fat diet. K ATP channel-mediated relaxation responses, currents, and K ATP expression in VSMC of both aortas and mesenteric arteries were inhibited in these rats. Conclusion: Altered ATP-sensitive potassium channels in obese rats may underscore obesity-triggered increase in blood pressure. |
| Databáze: | OpenAIRE |
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