Structure-Guided Tuning of a Hydroxynitrile Lyase to Accept Rigid Pharmaco Aldehydes

Autor:	Fu-Long Li, Jian-He Xu, Hui-Lei Yu, Ran Hong, Guo-Qiang Lin, Yu-Cong Zheng, Zuming Lin
Rok vydání:	2020
Předmět:	Hydroxynitrile lyase 010405 organic chemistry Stereochemistry General Chemistry Protein engineering 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Hydrocyanation Pharmacophore Bifunctional Vicinal Cyanohydrin
Zdroj:	ACS Catalysis. 10:5757-5763
ISSN:	2155-5435
DOI:	10.1021/acscatal.0c01103
Popis:	The chiral vicinal C–O/C–N bifunctional groups generated from enzymatic hydrocyanation represents a useful methodology. However, construction of the pharmacophore of β2-adrenoreceptor agonists with...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c8f71399edd23ecb8e41f7a9617d84df https://doi.org/10.1021/acscatal.0c01103 Zobrazit plný text záznamu