Synthesis of 2-Aryl-4-(R-sulfanylmethyl)-3-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones

Autor:	Mykhaylo A. Potopnyk, N. D. Obushak, V. S. Matiichuk
Rok vydání:	2010
Předmět:	Pyridazine chemistry.chemical_compound Methylhydrazine chemistry Aryl Organic Chemistry Hydrazine chemistry.chemical_element Organic chemistry Halogenation Alkylation Ring (chemistry) Sulfur
Zdroj:	Russian Journal of Organic Chemistry. 46:1550-1557
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428010100192
Popis:	Bromination of ethyl 1-aryl-4-acetyl-5-methyl-1H-pyrazole-3-carboxylates gave ethyl 1-aryl-4-(bromoacetyl)-5-methyl-1H-pyrazol-3-carboxylates which were used to alkylate benzenethiol and heterocyclic thiones at the sulfur atom. Reactions of the resulting S-alkylation products with hydrazine or methylhydrazine involved closure of pyridazine ring to afford 2-aryl-3-methyl-4-[phenyl(or hetaryl)sulfanylmethyl]-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c8f4f6a1f339aa6b7ed8972535e41273 https://doi.org/10.1134/s1070428010100192 Zobrazit plný text záznamu Plný text ve formátu PDF