A Practical Synthesis of Optically Active Platelet-Activating Factor Antagonist, (+)-6-(2-Chlorophenyl)-3-cyclopropanecarbonyl-8,11-dimetyl-2,3,4,5-tetrahydro-8H-pyrido(4',3':4,5)thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine(E6123), and Its Absolute Configuration

Autor:	Hiroyuki Yoshimura, Shigeru Souda, Tetsuya Kawahara, Yutaka Yoshida, Shuhei Miyazawa, Tadashi Sato, Kazuo Okano, Osamu Asano, Yoshimasa Machida, Isao Yamatsu, Naoyuki Shimomura, Takatoshi Kawai
Rok vydání:	1992
Předmět:	Platelet-activating factor Chemistry Stereochemistry medicine.drug_class Antagonist Absolute configuration General Chemistry General Medicine Crystal structure Optically active Receptor antagonist chemistry.chemical_compound Diazepine Drug Discovery medicine Platelet activating factor antagonist
Zdroj:	Chemical and Pharmaceutical Bulletin. 40:521-523
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.40.521
Popis:	Optically active platelet-activating factor (PAF) receptor antagonist, (+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8, 11-dimethyl-2, 3, 4, 5-tetrahydro-8H-pyrido[4', 3' : 4, 5]thieno[3, 2-f][1, 2, 4]triazolo[4, 5-a][1, 4]diazepine (E6123), was synthesized on large-scale by optical resolution using (+)-dibenzoyl-D-tartaric acid. An X-ray crystallographic analysis clearly indicated that the absolute configuration of the synthesized E6123 was S.
Databáze:	OpenAIRE
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