LH – RH Analogue Treatment in Adenocarcinoma of the Pancreas: A Phase II Study
| Autor: | C. Martinoli, M. Onetto, R. Lionetto, L. Fazzuoli, G. Rollandi, S. Saccomanno, A. Allegretto, V. Pugliese, M. Marugo, Michela Paganuzzi |
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| Rok vydání: | 1993 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Chemotherapy Pancreatic disease business.industry medicine.medical_treatment Goserelin Urology Phases of clinical research General Medicine medicine.disease medicine.anatomical_structure Internal medicine Pancreatic cancer medicine Adenocarcinoma Stage (cooking) Pancreas business medicine.drug |
| Zdroj: | Oncology. 50:77-80 |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | In this phase II study, we treated 7 patients, all males, with stage III or IV pancreatic cancer with goserelin (an LH-RH analogue). Goserelin was administered at a dose of 3.6 mg every 4 weeks. The tumour response was assessed by measuring lesions with US- or CT-scan studies, according to WHO criteria. No response was observed. The median survival was 8 months in locally unresectable tumours and 4 months in advanced disease. The accrual was actually stopped at 7 cases because there were no responses in either of our series or in those published during our study. The authors conclude that the treatment with LH-RH analogue alone cannot be recommended for further studies. |
| Databáze: | OpenAIRE |
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