Low-Molecular-Weight Mimetic of BDNF Loop 2 Reduces Ethanol Consumption in Female Rats

Autor:	N. M. Sazonova, Tatiana A Gudasheva, Andrey D. Durnev, E. M. Grigorevskikh, A. V. Nadorova, L. G. Kolik
Rok vydání:	2021
Předmět:	Ethanol preference medicine.medical_specialty Ethanol Alcohol General Medicine Alcohol craving General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Endocrinology chemistry In vivo Neurotrophic factors Internal medicine Male rats medicine
Zdroj:	Bulletin of Experimental Biology and Medicine. 171:441-444
ISSN:	1573-8221 0007-4888
Popis:	The study examined the effect of GTS-201, a low-molecular weight mimetic of brain-derived neurotrophic factor (BDNF) loop 2, on persistent alcohol craving in outbred male and female albino rats with ethanol preference score ~50% developed in the free choice paradigm between 10% ethanol and water over 24 weeks. Both single and subchronic (5 days) injections of GTS-201 in a daily dose of 5 μg/kg reduced alcohol deprivation effect in female, but not in male rats. The possibility of in vivo sex-dependent regulation of modeled alcohol craving with a low-molecular-weight dipeptide mimetic of BDNF loop 2 was demonstrated and sex-related differences in this effect were revealed
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c8e44ccb40948178e2687efefae38dbf https://doi.org/10.1007/s10517-021-05245-w Zobrazit plný text záznamu Full text from SpringerLink