A pilot study of associated factors of weight changes in community-dwelling patients with Alzheimer's disease
| Autor: | Linda Lam, Jean Woo, Helen F.K. Chiu, Mandy W.M. Kwan, Timothy Kwok |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics business.industry Endocrinology Diabetes and Metabolism Weight change Anthropometry medicine.disease Endocrinology Weight loss Internal medicine medicine Physical therapy Dementia Alzheimer's disease medicine.symptom Prospective cohort study business Bioelectrical impedance analysis Body mass index |
| Zdroj: | Nutrition Research. 25:111-118 |
| ISSN: | 0271-5317 |
| Popis: | The objective of this investigation was to identify associated factors for weight changes in Alzheimer's disease (AD) patients. The prospective study was conducted on 20 early AD, 25 late AD psychogeriatric outpatients all over 60 years of age with family caregiver(s), and 36 normal older people as control subjects. Body anthropometry was assessed in subjects including bioelectric impedance analysis and indirect calorimetry. Total daily energy expenditure (TDEE) was estimated by questionnaire. Three-day food records and neuropsychiatric inventory were recorded. Fasting blood was analyzed for plasma tumor necrosis factor (TNF). All subjects were weighed again 6 months later. In this study the AD subjects were thinner, less physically active, but had greater caloric and protein intakes than the control subjects. The percentage weight change in the AD subjects correlated inversely with TDEE, body mass index, and plasma TNF concentration (Pearson correlation coefficient ‒0.40, ‒0.43, Spearman correlation coefficient ‒0.31, respectively). In conclusion, physically active AD subjects are at risk of weight loss and plasma TNF may play a role in this condition. |
| Databáze: | OpenAIRE |
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