Evaluation of IL-10, IFN-γ, and thiol–disulfide homeostasis in patients with drug-resistant epilepsy
| Autor: | Adnan Kirmit, Mehtap Kocatürk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Neurology Dermatology medicine.disease_cause Proinflammatory cytokine 03 medical and health sciences Epilepsy 0302 clinical medicine Internal medicine Medicine Interferon gamma 030212 general & internal medicine chemistry.chemical_classification business.industry General Medicine Drug Resistant Epilepsy medicine.disease Psychiatry and Mental health Endocrinology chemistry Thiol Neurology (clinical) business 030217 neurology & neurosurgery Oxidative stress Homeostasis medicine.drug |
| Zdroj: | Neurological Sciences. 43:485-492 |
| ISSN: | 1590-3478 1590-1874 |
| Popis: | This study compared dynamic thiol–disulfide homeostasis (an oxidative stress marker), anti-inflammatory interleukin-10 (IL-10) levels, and proinflammatory interferon gamma (IFN-γ) levels in drug-resistant epilepsy patients with those in patients with well-controlled epilepsy and healthy controls. This prospective cross-sectional study enrolled 89 people: 27 with drug-resistant epilepsy, 30 with well-controlled epilepsy, and 32 healthy controls matched in demographic characteristics. The mean serum IL-10 levels were significantly lower and the mean serum IFN-γ levels significantly higher in the drug-resistant epilepsy patients compared to the well-controlled epilepsy and healthy control groups. The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower, and the disulfide (SS) levels were significantly higher in the drug-resistant group than in the other two groups. The significant differences in thiol–disulfide homeostasis and IL-10 and IFN-γ levels in the drug-resistant epilepsy group suggest that these markers indicate a poor prognosis in epilepsy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink