Development of a Refractory Stage in a Dog Model for Phenylketonuria

Autor:	C. Cooley, E. de la Pava, S.D. Sharma, C.M. Ambrus
Rok vydání:	1982
Předmět:	medicine.medical_specialty Phenylalanine hydroxylase biology Phenylketonurias business.industry Urology Phenylalanine Dog model Endocrinology Refractory Internal medicine medicine biology.protein Fenclonine business medicine.drug
Zdroj:	Journal of Urology. 127:200-201
ISSN:	1527-3792 0022-5347
DOI:	10.1016/s0022-5347(17)53699-x
Popis:	Dogs were fed a continuous diet of phenylalanine (Phe) daily and para-chloro-phenylalanine (p-CPhe), an inhibitor of phenylalanine hydroxylase (PH-ase) every second day. It was reported that such a diet produces a sustained hyperphenylalanemia in rats. We have found, however, that in dogs an initial rise in circulating Phe is followed, after a period of time, by a return to normal levels in spite of diet maintenance. PH-ase ws measured in liver samples obtained from dogs before the start of the above diet and at the time when Phe levels returned to normal. It was found that the post-feeding liver sample had 57%-100% less activity than the normal sample. Accordingly, decline in Phe levels cannot be attributed to an increase in PH-ase activity. Experiments are being initiated using labelled Phe, to investigate whether chronic feeding of Phe and p-CPhe resulted in an intestinal block to Phe absorption, which may explain our experimental findings.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c8dffaad4e730331e1da317b1e9f80e0 https://doi.org/10.1016/s0022-5347(17)53699-x Zobrazit plný text záznamu