ATP-Dependent and Calcium Mechanisms of the Effects of Salicylates on Electrical Potentials in Neurons in the Mollusk Helix Albescens
| Autor: | T. V. Gamma, D. R. Khusainov, I. V. Cheretaev, O. I. Kolotilova, Nozdrachev Ad, I. I. Korenyuk |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
General Neuroscience Electrical potentials chemistry.chemical_element Helix albescens Zinc Calcium 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Biochemistry chemistry medicine Biophysics Extracellular Neuron Adenosine triphosphate 030217 neurology & neurosurgery Intracellular |
| Zdroj: | Neuroscience and Behavioral Physiology. 46:644-651 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-016-0291-0 |
| Popis: | This report presents our studies of the ATP-dependent and calcium mechanisms of the effects of salicylates on the electrical activity of neurons in the mollusk Helix albescens Rossm. Adenosine triphosphate (5·10–4 M) added simultaneously with salicylates in the extracellular medium significantly modified their neurotropic effects, eliminating the nonselective suppression of neuron spike activity by acetylsalicylic acid and increasing the activatory influences of cobalt and zinc acetylsalicylates. Blockade of uptake of Ca2+ into the neuroplasm from the extracellular medium and intracellular depots with 5·10–5 M and 5·10–4 M CdCl2 and BaCl2 had no significant effect on neuron responses to salicylates, suggesting that calcium mechanisms are not involved. |
| Databáze: | OpenAIRE |
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