The synthesis of (9S)-9-alkyl-9-hydroxyerythromycin A derivatives and their ketolides

Autor:	Deodialsingh Guiadeen, Eugene B. Grant, Jesse M. Weiss, Sigmond G. Johnson, Stuart Hayden, William V. Murray, Mark J. Macielag, Shawn Branum
Rok vydání:	2005
Předmět:	chemistry.chemical_classification Chemical transformation chemistry Stereochemistry Organic Chemistry Drug Discovery Stereoselectivity Biochemistry Combinatorial chemistry Alkyl
Zdroj:	Tetrahedron Letters. 46:2731-2735
ISSN:	0040-4039
Popis:	A short, concise synthesis of a novel series of (9S)-9-alkyl-9-hydroxyerythromycin A derivatives and their corresponding ketolides, is described. The key chemical transformation is a stereoselective addition of organomagnesium or organolithium agents to the 9-position of the suitably protected macrolide templates 8 and 13.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c8bc67257998d96a8bf39b2f2a02973a https://doi.org/10.1016/j.tetlet.2005.02.162 Zobrazit plný text záznamu Full Text from ScienceDirect