The synthesis of (9S)-9-alkyl-9-hydroxyerythromycin A derivatives and their ketolides
Autor: | Deodialsingh Guiadeen, Eugene B. Grant, Jesse M. Weiss, Sigmond G. Johnson, Stuart Hayden, William V. Murray, Mark J. Macielag, Shawn Branum |
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Rok vydání: | 2005 |
Předmět: | |
Zdroj: | Tetrahedron Letters. 46:2731-2735 |
ISSN: | 0040-4039 |
Popis: | A short, concise synthesis of a novel series of (9S)-9-alkyl-9-hydroxyerythromycin A derivatives and their corresponding ketolides, is described. The key chemical transformation is a stereoselective addition of organomagnesium or organolithium agents to the 9-position of the suitably protected macrolide templates 8 and 13. |
Databáze: | OpenAIRE |
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