HER2 gene status and the relationship with p21 protein expression in gastric cancer

Autor: Yangkun Wang, Xutao Yuan, Jinsheng Song, Yongjie Li, Nianlong Meng, Fulin Li, Xianwei Zhang
Rok vydání: 2011
Předmět:
Zdroj: The Chinese-German Journal of Clinical Oncology. 10:162-165
ISSN: 1613-9089
1610-1979
DOI: 10.1007/s10330-011-0760-4
Popis: We aimed to analysis the HER2 gene status and its relationship with p21 protein expression in gastric carcinoma. Fluorescence in situ hybridisation (FISH) and immunohistochemistry (IHC) techniques were used to detect HER2 gene status and p53 protein in 59 cases of gastric cancer. FISH detection of HER2 gene amplification rate was 16.9% (10/59), HER2 gene amplification in 49 cases without copy number gain and gene amplification were a total of 49.2% (29/59). HER2 protein expression was 42.4% (25/59), HER2 gene amplification rates in patients with +++, ++ HER2 protein expression were 3/3 and 5/8, while in patients with + HER2 protein expression, it was 2/14, there was significant difference (P 0.05). HER2 gene amplification rate and gene copy number had positively correlation with p21 protein expression, HER2 gene status and expression of p21 protein combined detection can provide a reference value in gastric cancer metastasis, patient’s condition development and prognosis, it also can guide clinical development of individual treatment.
Databáze: OpenAIRE
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