Dual Stimuli Responsive Gelatin-CNT Hybrid Films as a Versatile Tool for the Delivery of Anionic Drugs
| Autor: | Orazio Vittorio, Manuela Curcio, Francesca Iemma, Silke Hampel, Giuseppe Cirillo, Nevio Picci, Umile Gianfranco Spizzirri, Fiore Pasquale Nicoletta |
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| Rok vydání: | 2016 |
| Předmět: |
Ketoprofen
Materials science food.ingredient Polymers and Plastics Stimuli responsive General Chemical Engineering 02 engineering and technology Carbon nanotube 010402 general chemistry 01 natural sciences Gelatin law.invention food Molecular size law Polymer chemistry Materials Chemistry medicine Bovine serum albumin biology Organic Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Polymerization Drug delivery biology.protein 0210 nano-technology Nuclear chemistry medicine.drug |
| Zdroj: | Macromolecular Materials and Engineering. 301:1537-1547 |
| ISSN: | 1438-7492 |
| Popis: | Hybrid hydrogel films able to modulate the release of anionic species, ketoprofen (Ket) and bovine serum albumin (BSA), as a function of their molecular size are prepared by UV-induced polymerization of methacrylated gelatin in the presence of oxidized multiwalled carbon nanotubes (MWNT_COOH). The dual-stimuli responsive composites can modulate the release in response to the variation of temperature and the application of an external voltage. Drug release profiles, analyzed by mathematical models, show that different temperatures (25 and 45 °C) and applied voltages (0 and 36 V) have a different effect on the release of the two therapeutics. Ket release is enhanced at 45 °C (77% vs 22% at 25 °C) with the maximum value recorded when 36 V is applied (94%). An increase in the amount of released BSA is recorded at 45 °C (96% vs 50% at 25 °C), while the application of the external voltage reduces this value (39%). |
| Databáze: | OpenAIRE |
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