Cocrystallization-driven self-assembly with vanillic acid offers a new opportunity for surmounting fast and excessive absorption issues of antifungal drug 5-fluorocytosine: a combined theoretical and experimental research
| Autor: | Fan-Zhi Bu, Yue-Ming Yu, Yu-Li Shen, Lu Liu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | CrystEngComm. 24:2777-2790 |
| ISSN: | 1466-8033 |
| DOI: | 10.1039/d2ce00114d |
| Popis: | The cocrystal of 5-fluorocytosine (FCY) with vanillic acid (VAA) was assembled via a cocrystallization technique, giving a novel understanding for conquering the dose-limited hepatotoxicity caused by the rapid and almost complete absorption of FCY. |
| Databáze: | OpenAIRE |
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