Synthesis and in‐vivo taste assessment of meloxicam pivalate

Autor:	Mariam S. Degani, Bandoo C. Chatale
Rok vydání:	2019
Předmět:	Drug Taste media_common.quotation_subject Rat model Pharmaceutical Science Arthritis 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine stomatognathic system In vivo Drug Discovery medicine Palatability media_common Chemistry Organic Chemistry Prodrug 021001 nanoscience & nanotechnology medicine.disease Meloxicam 0210 nano-technology medicine.drug
Zdroj:	Drug Development and Industrial Pharmacy. 45:1590-1598
ISSN:	1520-5762 0363-9045
DOI:	10.1080/03639045.2019.1628250
Popis:	Meloxicam (MX), a nonsteroidal anti-inflammatory drug, widely used to treat arthritis, has a very bitter taste. Chemical modification of the bitter functionality was achieved by synthesis of a prodrug, meloxicam pivalate (MXP). Taste improvement was evaluated using single bottle-test rat model. It was found that palatability of MXP solution improved significantly as compared to MX.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c89f8002afa66035647c99834b964eb7 https://doi.org/10.1080/03639045.2019.1628250 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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