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Purpose of Review: One of the vital functions of the nervous system is to provide information about the threat of injury . The sensation of pain by its inherent aversive nature, contributes to this function. The mainstay of medical pain therapy remains drugs that have been around for decades, like opiates and non -opioid drugs. However, adverse effects of opiates, particularly tolerance, limit their clinical use. Several lines of investigations have shown thatsystemic administration of non -opioid, non-steroidal anti -inflammatory drugs (NSAIDs) induces antinociception with some effects of tolerance. In this review, we report that repeated microinjections of NSAIDs analgin, clodifen, ketorolac and xefocam into th e |
