Studies on NaI/DMSO inducedretro-Michael addition (RMA) reactions on some 1,5-dicarbonyl compounds

Autor:	S. Jothilingam, H. Surya Prakash Rao
Rok vydání:	2005
Předmět:	Fragmentation (mass spectrometry) Chemistry Electrophile Michael reaction Halide General Chemistry Photochemistry Medicinal chemistry
Zdroj:	Journal of Chemical Sciences. 117:27-32
ISSN:	0973-7103 0253-4134
Popis:	Studies on the reaction of some 1,5-ketodiesters/1,5-diketones with NaX (X = Cl/Br/I)/DMSO have shown that under microwave/thermal conditions, facileretro-Michael addition (RMA) reaction takes place instead of formation of the expected Krapcho products. Mechanistic studies have shown that the NaI/DMSO system is a better system than NaCl/DMSO or NaBr/DMSO to promote the RMA pathway and DMSO is an essential requirement. The electrophilic halide ion could be involved in this fragmentation reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c899d48bd787b4a7e79a699e0f870cb6 https://doi.org/10.1007/bf02704358 Zobrazit plný text záznamu Full text from SpringerLink