Action of tetanus toxin and colchicine on synaptic membranes of the rat cerebral cortex
| Autor: | Rozhanets Vv, Rodina Vi, Glebov Rn, G. N. Kryzhanovskii, Yu. G. Sandalov |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
biology
Toxin Chemistry Tetanus ATPase Stimulation General Medicine Pharmacology medicine.disease_cause medicine.disease General Biochemistry Genetics and Molecular Biology In vitro chemistry.chemical_compound medicine.anatomical_structure Cerebral cortex medicine biology.protein Colchicine Free nerve ending |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 83:129-132 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00799399 |
| Popis: | Purified tetanus toxin (TT), in experiments in vitro, was shown to affect neither the Na,K-ATPase activity of the synaptic membrane fraction of the rat cerebral cortex nor the inhibition of Na,K-ATPase activity produced by electrical stimulation of a suspension of synaptic membranes, nor the binding of GABA-3H by synaptosomes. TT and colchicine (1 mM) reduced the osmotic sensitivity of the nerve endings. Colchicine, in low concentrations (10−5 to 10−3 M), does not affect Mg- and Na,K-ATPase but, in higher concentrations (10−2 M), it inhibits the activity of both ATPases considerably. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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