| Popis: |
A novel total synthesis of (dl)-prostaglandin F1α methyl ester is described. The 2,3-dialkyl-1,4-cyclopentanediol system is obtained by the reduction of an appropriate 2,3-dialkyl-4-hydroxy-2-cyclopentenone. The facile conversion of the most abundant isomeric cyclopentanediol, with the all trans relation of the four substituents to a δ-lactone enables the creation of the required prostaglandin configuration and the construction of the C-12 side chain. Extensive spectroscopic data are included. |
