Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis via scintigraphy
| Autor: | Rakesh Raj, Ankur Kaul, Pooja Mongia Raj, Alpana Ram, Anil K. Mishra |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Biodistribution
010304 chemical physics Chemistry General Chemical Engineering Kinetics Infrared spectroscopy 02 engineering and technology General Chemistry 021001 nanoscience & nanotechnology 01 natural sciences chemistry.chemical_compound 0103 physical sciences Drug delivery Curcumin Zeta potential Particle size Nanocarriers 0210 nano-technology Nuclear chemistry |
| Zdroj: | RSC Advances. 8:20809-20821 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c8ra01898g |
| Popis: | In the present investigation we have prepared and characterized curcumin (CN)-containing chitosan nanoparticles (CS-NPs) coated with Eudragit FS 30D for colon-specific drug delivery for treatment of ulcerative colitis. Methods: CS-NPs were prepared by ionic gelation using tripolyphosphate. To specify pH sensitive delivery, CS–CN-NPs were coated with Eudragit FS 30D by using a solvent evaporation method. Different process parameters were evaluated, and the optimized formulation was characterized by particle size, size distribution, zeta potential and encapsulation efficiency before lyophilization. The lyophilized product was further subjected to Fourier-transform infrared spectroscopy, and particle morphology and in vitro drug release in different media were studied. Results: the kinetics of in vitro drug release from the CS–CN-NPs revealed sustained release behaviour of the developed carriers. In vivo biodistribution study by gamma-scintigraphy showed good accumulation of the developed nanocarriers in the colonic region. Conclusion: sustained and pH stimulated delivery of CN to the colon was successfully attained via coating of CS-NPs with Eudragit FS 30D to circumvent poor absorption and availability of CN. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|